In particular, the study of orexin knock‐out (KO) mice, which recapitulates the human narcolepsy type‐1 phenotype (Chemelli et al., 1999), may help to focus on the specific contribution of orexin deficiency on the narcolepsy phenotype across the lifespan, which may be especially relevant in light of the recent development of orexin receptor agonists for the treatment of NT1 (Dauvilliers et al., 2023). This evidence concerns the gene HCRT and narcolepsy.