In LC, MCM8 shows high expression in lung adenocarcinoma (LUAD) tumour tissues from The Cancer Genome Atlas (TCGA), and upregulation of MCM8 is associated with poor overall survival (OS) of patients with LUAD20, 21; however, the function of MCM8 in LC development is unknown, and was the focus of this study. The gene discussed is MCM8; the disease is lung adenocarcinoma.