MAVS and neoplasm: We compared the tumor growth of WT, Mavs−/−, Tmem173−/−, and Ifnar−/− mice that were vaccinated with ME49Δompdc, and found the potent anti‐tumor efficiency of ME49Δompdc vaccination was dismissed in those IFN‐I signaling deficient mice (Figure S8A,B, Supporting Information), and ME49Δompdc vaccination no longer altered the expression of these tumor‐associated genes when mice lacked IFN‐I and downstream signaling (Figure S8C,D, Supporting Information).