Due to the lack of GRA4, a negative regulator that hijacks host TBK1, vaccination with ME49Δompdc/gra4 results in stronger IFN‐I responses and induces IFN‐I‐dependent CD11b+CD64+MAR‐1+ dendritic cells (DCs), which in turn activate potent T cell responses to prevent tumor growth. The gene discussed is FCGR1A; the disease is neoplasm.