VEGFA and age-related macular degeneration: Predominant posterior segment diseases, such as DR, AMD, retinal vein occlusion, pathologic myopia, retinitis pigmentosa, uveitis, and retinoblastoma, are increasingly impacting populations globally, culminating in profound visual impairments and irreversible blindness.[8] These disorders share several common pathophysiological mechanisms, including involvement of VEGF, reactive oxygen species (ROS) and oxidative stress, macrophages, RPE damage, mitochondrial dysfunction, and matrix metalloproteinases.