Senescent‐like microglia in aged animals demonstrate elevated transcript levels for a range of SASPs (Stojiljkovic et al., 2022), including IL‐10, IL1B, IL‐6, TNFA, and BDNF, all of which may contribute to epilepsy and seizure vulnerability (Vezzani et al., 2017; Vezzani & Granata, 2005). Here, IL1B is linked to epilepsy.