Many autoimmune diseases (AIDs) are closely associated with hyperinflammatory responses.[19] Rheumatoid arthritis (RA), a frequently occurring and deadly AID, is distinguished by chronic systemic inflammation.[20] To investigate the clinical significance of RNF13‐LAMP‐1 molecular axis, we analyzed the protein level of RNF13 and LAMP‐1 in peripheral blood mononuclear cells (PBMCs) from healthy controls (HC) people and newly diagnosed RA patients. Here, RNF13 is linked to rheumatoid arthritis.