The pivotal role of tumor‐intrinsic IFN in reversing the non‐MSI TME and improving immunotherapy response has been previously confirmed.[8, 15] Herein, our analysis, integrating scRNA‐seq and bulk RNA‐seq data from publicly available datasets, identified KDM3A as a regulator of gene expression related to tumor‐intrinsic IFN signaling, important for altering the immunologically non‐MSI TME in gastric cancer. The gene discussed is IFNA1; the disease is gastric cancer.