IFNA1 and neoplasm: Chromatin modifications have been shown to play a role in reshaping the TME, regulating tumor growth, and influencing the immunotherapy response,[7a,b] and previous studies have reported that epigenetic genes can regulate tumor‐intrinsic IFN through chromatin modification processes.[14] To investigate this further, we conducted a correlation analysis between histone modification genes and IFN gene sets using datasets from the TCGA, GSE184336 and ACRG cohorts (Figure 2A).