These findings are consistent with previous studies that reported tumor‐intrinsic IFN induces the infiltration of IFNγ+ CD8 T cells and reduces Treg cell numbers, ultimately enhancing the response to immunotherapy.[15, 19] High levels of Treg cells are associated with an immunosuppressive TME,[20] while IFNγ+ CD8 T cells contribute to an immune‐activated TME focused on eliminating tumor cells.[21] Moreover, we conducted a comprehensive analysis of the immune landscape in KDM3A‐ablated tumors using single‐cell RNA sequencing of sorted CD45+ cells. Here, CD8A is linked to neoplasm.