ERVs can trigger a response similar to “viral mimicry”, including the activation of a double‐stranded RNA (dsRNA) response, leading to the stimulation of type I IFN production and the activation of ISGs.[8g–k] To investigate whether ERVs mediate the induction of tumor‐intrinsic IFN in response to KDM3A inhibition, we analyzed data from an no‐MSI TME in the GSE150290 dataset (Figure S5, Supporting Information). Here, IFNA1 is linked to neoplasm.