CDKN1A and cancer: For example, cyclin‐dependent kinase inhibitor 1A (CDKN1A), a tumor suppressor that is downregulated in multiple cancers,[29] is targeted by at least 28 miRs and many of which are upregulated together in cancers where CDKN1A has been implicated.[30] We found that the Trp centered miR complex works better than any individual miR on the inhibition of expression of targeted genes.