The conversations clarified areas in which further study is necessary and worthwhile, including studies on the mechanisms underlying sex‐dependent impacts of apoE isoforms, development of improved animal and cell models of AD and other apoE‐related diseases, clinical impact of modified apoE proteins (e.g., lipidated), and assessment of therapeutics targeting apoE‐related physiological aberrations. The gene discussed is APOE; the disease is Alzheimer disease.