Dysregulation of the gut microbiota disrupts the interaction between mucosal addressin cell adhesion molecule 1 (MAdCAM‐1) on high endothelial venules and integrin α4β7 expressed by Treg17 cells and leads to the relocation of Treg 17 cells into tumors and tumor‐draining lymph nodes(tdLNs), thereby affecting ICI efficacy.50 This evidence concerns the gene MADCAM1 and neoplasm.