The transition from prediabetes to diabetes has been linked to the presence of both pro- and anti-inflammatory indicators, including adiponectin, the recently discovered extracellular AGE-binding receptor (EN-RAGE), interleukin-6 (IL-6), IL-13, CRP, IL-18, IL-1 receptor antagonist, and neopterin [47]. Here, IL6 is linked to prediabetes syndrome.