A study involving cancer cell lines harboring FGFR1, FGFR2 and FGFR3 alterations has described consistent reduction in MYC protein level upon FGFR inhibition in FGFR inhibitor-responsive cancer cells, while MYC level remained intact in FGFR inhibitor-nonresponsive cells despite obvious FGFR signaling inhibition [136]. The gene discussed is FGFR3; the disease is cancer.