AKT1 and cancer: In this study, inhibition of the ERK pathway induced MYC protein level reduction, while the MYC protein level was not affected by AKT inhibition as well as by siRNAs against STAT3 or PLCɣ, suggesting that MYC protein stability is predominantly regulated by the FGFR-MEK-ERK signaling in FGFR aberrant cancers [136].