MYC and T-cell acute lymphoblastic leukemia: NOTCH signaling is an important oncogenic pathway in T-cell acute lymphoblastic leukemia (T-ALL), and NOTCH1 directly activates MYC expression via NMe” (for NOTCH MYC enhancer), a long-range MYC enhancer located 1.4 Mb downstream of the MYC locus [115, 121].