A significant difference in the expression of NF-κB was found when the immunohistochemical labeling of RelA protein, the p65 component of NF-κB, was applied to normal colorectal mucosa (9.3%), colorectal adenoma (54.0%), and colorectal adenocarcinoma (71.9%) [226]. This evidence concerns the gene NFKB1 and colorectal adenoma.