The phenotypic and genotypic landscape of mesenchymal neoplasms harboring FET (EWSR1/FLI1)::CREB fusions, which was initially described as the genetic landmark of clear cell sarcoma of soft tissue, has been growing and now includes angiomatoid fibrous histiocytoma (AFH) and analogous intrapulmonary and intracranial neoplasms [7], and malignant gastrointestinal neuroectodermal tumors (MGNET) [8] and their extra-abdominal counterparts [9]. The gene discussed is CREB1; the disease is histiocytoma, Angiomatoid fibrous.