Fusions between members of the FET gene family (EWSR1 and FUS) and genes encoding for the CREB-transcription factor family (ATF, CREB1, and CREM) have been reported in a variety of clinically and pathologically distinct neoplasms of mesenchymal [1–4, 12–14], epithelial [10] and mesothelial [11] origin. The gene discussed is EWSR1; the disease is neoplasm.