These tumors comprise a heterogeneous category of old and new or emerging entities including morphologically defined sarcomas/neoplasms with EWSR1::CREB fusions and unclassified sarcomas with non-ETS EWSR1 fusions such as EWSR1::PATZ1 [5, 6] and EWSR1::NFATC2 fusions [6]. This evidence concerns the gene CREB1 and sarcoma.