Recently, EWSR1::CREM fusions have been reported in a novel tumor type characterized by epithelioid/round cell morphology, predominance of intra-abdominal location, lack of neuroectodermal/melanocytic immunophenotype, frequent expression of epithelial markers [12–14] and lack of defining features of the well-known EWSR1/FUS::CREB fusion entities [12–14]. This evidence concerns the gene FUS and neoplasm.