This therapy appears to be particularly effective in the case of tumors with higher tetraspanin 8 expression, such as colorectal cancer,36 glioblastoma,45, 47 melanoma,55 hepatocellular carcinoma,87 ovarian cancer,58, 88 and gastric cancer.50, 73. The gene discussed is TSPAN8; the disease is hepatocellular carcinoma.