MAPT and Alzheimer disease: As expected, this approach was successful in recapitulating multiple aspects of AD, including (1) induction of misfolded tau, both locally (ERC) and throughout interconnected regions; (2) coaptation of endogenous tau, leading to templating of macaque tau into pathological forms; (3) induction of neuroinflammation; and (4) alterations in AD core biomarkers in CSF and blood.9