Specifically, in this late‐middle‐aged and older adult cohort enriched for AD risk, the expected unfavorable age‐related changes in neuroinflammation (IL‐6 and S100B), synaptic dysfunction (Ng), and neurodegeneration (α‐Syn) were attenuated in KL‐VSHET. The gene discussed is S100B; the disease is Alzheimer disease.