While it was previously mentioned that zearalenone inhibits CRC growth in vivo by increasing the abundance of short-chain fatty acids-producing intestinal microbiota [99], another study found that zearalenone enhances GPER expression in colon cancer cell lines and activates the ERK1/2 and Hippo-YAP signaling pathways, thereby promoting cell proliferation [118]. This evidence concerns the gene GPER1 and colorectal carcinoma.