LIPE and lipodystrophy: FPLD is categorized into eight types: the molecular basis of FPLD1 is unknown; FPLD2 is associated with missense mutations in LMNA [220]; FPLD3 is linked to heterozygous mutations in PPARG [221, 222]; FPLD4 is caused by heterozygous mutations in PLIN1 [222]; FPLD5 is associated with homozygous nonsense mutations in CIDEC [223]; FPLD6 is related to homozygous mutations in LIPE [224]; FPLD7 is linked to heterozygous mutations in ADRA2A [225]; and the AKT-linked lipodystrophy subtype is associated with heterozygous mutations in AKT2 [226].