CLDN5 and ischemic stroke: 10-O-(N, N-dimethylaminoethyl) ginkgolide B methanesulfonate (XQ-1H) has been shown to normalize the expression of claudin-5, occludin, ZO-1, and β-catenin in ischemic stroke model mice, leading to reduced BBB permeability and protection against oxygen–glucose deprivation/reoxygenation injuries [292].