This was likely because m6A modification is mainly installed by Mettl3/Mettl14 in the RRm6ACH motif near the stop codon of thousands of mRNA transcripts [32], but METTL16 has been reported to only target Mat2a, U6, metastasis associated lung adenocarcinoma transcript (Malat), branched chain amino acid transaminase 1 (Bcat1), and Bcat2 [15, 33, 34]. The gene discussed is MAT2A; the disease is lung adenocarcinoma.