ADAM10 and Alzheimer disease: The mature/pro-forma (mat/pro) ratio for ADAM10 was slightly increased in the brain tissues of AD + ALA, although this did not reach significance (AD + ALA: 97.79% ± 5.20% vs. AD + Veh: 89.58% ± 5.39%; P > 0.05; Fig. 2H, I).