Luo et al. [33] reported that inhibiting the TLR4/NF-κB/NLRP3 signaling pathway regulated the microglial polarization to improve motor function in cerebral ischemia mice, demonstrating the interplay of NF-κB and NLRP3 inflammasome [24, 26]. The gene discussed is NFKB1; the disease is brain ischemia.