A study by Guo et al. has shown that lncRNA ZFAS1 has several small open reading frames (smORF), one of which has been proven to be up-regulated in HCC tumor tissue, but is scarcely expressed in normal liver tissue, which implies that smORF may be related to the occurrence and development of hepatocellular carcinoma. Here, ZFAS1 is linked to hepatocellular carcinoma.