This study revealed that samples with elevated PHF5A expression had high TIDE scores in the majority of malignancies, indicating that patients with elevated PHF5A expression were more prone to tumor immune evasion, which is in line with our subsequent findings that in samples that were positive for PHF5A expression, CD3+, CD4+, and CD8 + T cells were concentrated in the tumor periphery and rarely infiltrated the tumor parenchyma. Here, CD4 is linked to neoplasm.