CD4 and hepatocellular carcinoma: In the study cohort, CD3+, CD4+, and CD8 + T cells were evenly scattered in the HCC tumor parenchyma in samples that were negative for PHF5A expression (Fig. 8A), whereas in samples that were positive for PHF5A expression, CD3+, CD4+, and CD8 + T cells were concentrated in the tumor periphery and rarely infiltrated the tumor parenchyma (Fig. 8B).