Therefore, this research systematically explored PHF5A expression and its correlation with prognosis, tumor mutation burden (TMB), microsatellite instability (MSI), functional status and tumor immunity across cancers and validated PHF5A expression and its association with survival, immune evasion, angiogenesis, and treatment response in HCC, with the aim of presenting a novel prognostic biomarker and therapeutic target for cancer treatment. The gene discussed is PHF5A; the disease is hepatocellular carcinoma.