Inflammatory cell-derived MYDGF deficiency aggravated endothelial LDL-C transcytosis, drove LDL-C uptake by the artery wall, and thus exacerbated atherosclerosis, whereas MYDGF inhibited MAP4K4 phosphorylation, enhanced AKT-1 activation, reduced the FoxO3a signaling cascade, and inhibited LDL transcytosis to protect against atherogenesis (Xu et al. 2023). The gene discussed is MAP4K4; the disease is atherosclerosis.