MYDGF and diabetic kidney disease: There is evidence that GLP-1 can ameliorate DKD (Mann et al. 2017; Fujita et al. 2014), and MYDGF can stimulate the production and secretion of GLP-1 by intestinal L cells in diabetic mice (Wang et al. 2020a, b), which may be one of the important mechanisms for its protective effect against DKD.