In addition, several studies have shown that cellular miR-486 is a multifunctional miRNA involved in many cancers, including the tumorigenesis of hepatocellular carcinoma, with additional functional roles as a modulator for regulating drug resistance, such as sorafenib resistance, by targeting FGFR4 and EGFR, thus offering a potential target for HCC treatment [44–47]. The gene discussed is FGFR4; the disease is hepatocellular carcinoma.