CAF promotes cancer progression through oncogenic functions, including the secretion of many different growth factors and proinflammatory cytokines, such as transforming growth factor beta (TGF-β), interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), and C-X-C motif chemokine 12 (CXCL-12) [14–18]. Here, CXCL12 is linked to cancer.