There are several immunogenic CD8 T cell epitopes described for GBM, especially in the highly expressed proteins, such as Epidermal Growth Factor Receptor (EGFR), Isocitrate Dehydrogenase 1 (IDH1), Phosphatase and Tensin homolog (PTEN), and Tumor Protein 53 (TP53). The gene discussed is EGFR; the disease is glioblastoma.