We also notice that the expression of KIR2DL4, another receptor of HLA-G that is upregulated on NK cells to mediate the immune suppression in cancer patients (LeMaoult et al, 2005; Zheng et al, 2021), displays no significant change on NK cells in ATB patients, which finding is further supported by the co-culture experiment data showing that Mtb-infected macrophages have little effect on NK cells expressing KIR2DL4. The gene discussed is HLA-G; the disease is cancer.