Gene set enrichment analysis (GSEA) revealed that genes involved in multiple inflammatory pathways [such as Toll-like receptor (TLR), NOD-like receptor (NLR), and TB-related signaling pathways] and apoptosis were upregulated, while genes related to phosphoinositide-3 kinase (PI3K)-AKT and RAP1 signaling pathways were downregulated, in NK cells from ATB group as compared to that from HC or LTBI group (Fig. 1B). This evidence concerns the gene AKT1 and tuberculosis.