These patients showed drastically reduced overall survival (Zuazo et al, 2019) and their T-cells strongly co-upregulated PD-1 and LAG-3 following in vitro stimulation with human lung cancer A549-SC3 stimulator cells (Fig. 5B) as described in (Edwards et al, 2022; Zuazo et al, 2019). This evidence concerns the gene LAG3 and lung cancer.