While Valès et al.4 concluded that in vitro IL-1 is released by the tumor epithelial cells, we herein demonstrate that in vivo, in particular within the MC38 orthotopic model, the TME IL-1 secretion is restricted to myeloid cells, while no expression could be found in epithelial, nor in stromal cells (Fig. 4h and Supplementary Fig. 5g). The gene discussed is IL1A; the disease is neoplasm.