To define the possible effect of tumor monocyte-derived IL-1 on the immunomodulatory reprogramming of EGCs, we isolated tumor- and bone marrow (BM)-derived monocytes from mice bearing orthotopic colon tumors and exposed primary enteric glia to their supernatant with or without IL-1R blockade (Fig. 5a). Here, IL1A is linked to colonic neoplasm.