At 24 h post-stimulation, the segregation of the samples was highly driven by the upregulation of several chemokines, cytokines and typical markers for pan-reactive astrocytes (Lnc2 and Timp1)21, suggesting an activated and immunomodulatory role for EGCs within the tumor microenvironment (Supplementary Fig. 3a, b). The gene discussed is TIMP1; the disease is neoplasm.