Strikingly, among the top differentially expressed CRC EGC genes, we identified the two key murine CRC EGC marker genes Lcn2 and Timp1. Using gene set enrichment analysis, we found that human EGC populations differentiate along the same homeostatic and tumor pathogenesis pathway transcriptomic signatures (Fig. 8e) as seen in our murine EGCs (Fig. 2e). This evidence concerns the gene TIMP1 and colorectal carcinoma.