These include antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), apoptosis induced by cross-linking of CD38 on the target cells, and immunomodulatory effects via elimination of CD38-positive (pos) immunosuppressive cells in the immune tumor microenvironment (TME) [10–12]. This evidence concerns the gene CD38 and neoplasm.