Based on the results of mass spectrometry analysis, among the many potential target proteins of USP32, given that USP32 is a deubiquitinating enzyme that regulates specific roles and mechanisms of malignant tumors through deubiquitination, we paid special attention to Bcl2-associated athanogene 3 (BAG3) proteins that can be degraded by the ubiquitin protease system in this study [37] (Fig. 3C). This evidence concerns the gene USP32 and cancer.