HMGB2 and hepatocellular carcinoma: In HCC, PART1 has been demonstrated to promote HCC progression by targeting the miR-590-3p/HMGB2 axis [17], and to promote proliferation, migration, and invasion by targeting the miR-149-5p/MAP2K1 axis [18]; it has been shown to enhance the proliferation and differentiation of Hep3B cells by targeting the miR-3529-3p/FOXC2 axis [16].