Using retroviral transduction of Ikzf1 deletion exon 4 to 7 (IK6) in pre-B acute lymphoblastic leukemia cell line (JM1), we developed a cell line model that recapitulated the phenotype of increased adhesion and stemness as observed in B-ALL mouse models and patient samples (10, 11). The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.