Additionally, JM1 IK6 showed altered gene expression signatures reminiscent of B-ALL blasts including increased expression of cell adhesion genes JUB and TIAM1 and decreased expression of B cell differentiation markers EBF1, Pax5, Spi1 (PU.1) and CD52 (Fig. 1C). This evidence concerns the gene SPI1 and acute lymphoblastic leukemia.