Aligning with our observations in vitro, SCLC-P tumorstreated with AU-24118 exhibited significant degradation of its direct targets(SMARCA2/4 and PBRM1), which ensued in downregulation of POU2F3, POU2F3coactivators, and downstream target GFI1B (Figure3C). The gene discussed is PBRM1; the disease is small cell lung carcinoma.