Immunohistochemistry (IHC) furtherconfirmed a dramatic loss of SMARCA4 and POU2F3 protein expression in theAU-24118-treated SCLC-P tumors, as well as decreased DCLK1 expression—atuft cell marker (Figures 3D and S3J). The gene discussed is SMARCA4; the disease is small cell lung carcinoma.