Collectively, this study identifies the mSWI/SNF chromatin remodelingcomplex as a vulnerability in POU2F3-dependent SCLC and POU2AF1-dependent MM.Combined with our previous findings in CRPC,23 these findings position mSWI/SNF ATPase degraders aspotential candidates for further optimization and clinical testing across variouscancer types, reinforcing the value of TF co-regulator targeting strategies inoncology. Here, POU2AF1 is linked to Miyoshi myopathy.