SCLCs are genetically driven by loss of function (LOF) alterations intumor suppressor genes RB1 and TP53,5 with distinct expressionpatterns of certain TFs or transcriptional regulators leading to four molecularsubtypes (SCLC-A, SCLC-N, SCLC-P, and SCLC-Y (YAP1)).6 Functional genomics analyses haveunderscored the critical roles of these TFs or coactivators in each SCLCmolecular subtype. This evidence concerns the gene RB1 and small cell lung carcinoma.