AKT1 and Arrhythmogenic right ventricular dysplasia: http://links.lww.com/MD/N195 The top 10 ranked major pathways: ECM-receptor interaction, focal adhesion, human papillomavirus infection, PI3K-Akt signaling pathway, arrhythmogenic right ventricular cardiomyopathy, hypertrophic cardiomyopathy, dilated cardiomyopathy, small cell lung cancer, protein digestion and absorption, and proteoglycans in cancer (Fig. 1D).