In addition, ECM modulation and immune cell infiltration are mediated by ITGA3.[29] MiR-223 downregulation improved ITGA3/ITGB1 signaling and aided in PCa cells’ ability to migrate and invade cancer cells.[30] Our immunohistochemical staining showed that these 3 genes were expressed higher in bladder tumor samples than in normal samples. The gene discussed is ITGB1; the disease is cancer.