http://links.lww.com/MD/N195 The top 10 ranked major pathways: ECM-receptor interaction, focal adhesion, human papillomavirus infection, PI3K-Akt signaling pathway, arrhythmogenic right ventricular cardiomyopathy, hypertrophic cardiomyopathy, dilated cardiomyopathy, small cell lung cancer, protein digestion and absorption, and proteoglycans in cancer (Fig. 1D). This evidence concerns the gene AKT1 and hypertrophic cardiomyopathy.