INS and type 2 diabetes mellitus: In this study, we investigated the feasibility and mechanism of slow-velocity eccentric-only resistance training on T2DM based on the results of insulin-resistant ECM collagen deposition in skeletal muscle with T2DM and the remodeling effect of eccentric training on skeletal muscle based on the role of MMP-2 and -9 in regulating extracellular matrix homeostasis.