PLA2R1 and ischemic stroke: A previous study in Chinese people suggested that a high level of anti-PLA2R antibodies may serve as an unfavorable predictor of ischemic stroke, which in turn implying a worse prognosis for kidney disease.[50] The study revealed elevated serum C1q levels in ischemic stroke patients.[51] Furthermore, ischemic neurons notably expressed C1q post-stroke, potentially facilitating the attack or clearance of damaged neurons and cellular debris.[52] The intricate relationship between PMN, classical complement pathways, and cerebrovascular diseases warrants comprehensive exploration.