AKT1 and neoplasm: It suppresses the SRC and PI3K/AKT/mTOR pathways by decreasing the phosphorylation of SRC at Tyr416 and AKT at Ser473, leading to antiproliferative and pro-apoptotic effects.[52] Cisplatin hinders tumor cell proliferation and triggers cell death by creating intrastrand DNA crosslinks and forming DNA-protein adducts.