SLC5A5 and carcinoma: SLC5A5 is not only well known for its association with CHT but is also well known as a gene that can predict the possibility of cancer based on a blood test before thyroid cancer surgery.[30,31] In particular, SLC5A5 has a high correlation with thyroid follicular adenoma but not with carcinoma.[31] Early diagnosis is crucial because endocrine tumors are often diagnosed as carcinomas based on the extent of invasion into the surrounding tissues rather than the direct presence of malignant cells.