It can be seen that the keywords of early research include “induced sputum,” “bronchoalveolar lavage,” “methacholine,” “mast cells,” “nitric oxide” and “allergic asthma.” The keywords such as “severe asthma,” “innate lymphoid cells,” “thymic stromal lymphopoietin,” “NF-κB(nuclear factor-κ-gene binding),” “airway remodeling” and “NLRP3(nucleotide-binding oligomerization domain-like receptor protein 3) inflammasome” have appeared in recent years and continue to 2022. The gene discussed is NFKB1; the disease is allergic asthma.