However, due to the restricted use of other TNF inhibitors in pregnant women and the lack of valid report data in this patient group, there is still a need to be cautious about the issue of spontaneous miscarriage.[41] In comparison, this study identified unique positive signals for etanercept about bone diseases such as joint destruction (ROR = 17.53, 95% CI: 11.91–25.80), chondrolysis (ROR = 17.48, 95% CI: 10.02 to 30.51), and finger deformity (ROR = 16.71, 95% CI: 12.68–22.01), which may also be attributed to the progression of RA. Here, TNF is linked to rheumatoid arthritis.