TXN and coronary vasospasm: While some studies have specifically implicated nitric oxide (NO) deficiency, it is postulated to play a crucial role in the development of coronary vasospasm.[5] Alternative mechanisms of coronary vasospasm include increased phospholipase C activity.[6] Furthermore, coronary vasospasm is associated with elevated markers of oxidative stress and inflammation, including thioredoxin, C-reactive protein, and monocyte levels.[7] Certain behavioral traits, such as type A personality, panic disorder, and severe anxiety, have also been described as being associated with coronary vasospasm.[8]