AKT1 and chromosome-type aberration frequency: Furthermore, research has shown that activation of AKT1 can promote the production of NO, enhancing the vasodilation capacity of endothelial cells.[43] Moreover, Akt1 signaling is necessary for ischemic resolution postinjury and likely reflects the consequence of NO insufficiency critical for vascular repair.[44] The findings of this study provide new targets and strategies for the prevention and treatment of CSA.