TG and Brain atrophy: Additionally, a reduction in brain volume is commonly observed on MRI scans, including those of our patient.[12,16] In a study by Kubota et al, delayed myelination was observed in 58.6% of patients, whereas brain atrophy was noted in 40.0% of patients.[6] Nonetheless, these imaging findings are nonspecific and provide less diagnostic value for MCT8 disorders than thyroid hormone abnormalities.