The molecular docking results showed that the key pharmacodynamic substances in PAD could be stably combined with the core target proteins TNF, GAPDH and IL6, indicating that PAD may act on TNF, GAPDH, IL6 and other targets, inhibit inflammatory responses, regulate cell proliferation and apoptosis, reduce the level of inflammatory factors, and regulate humoral and cellular immunity, so that it can be used for the treatment of acne. The gene discussed is GAPDH; the disease is peripheral arterial disease.