Through the analysis of CytoNCA plug-in, it was found that the most important active components in PAD were cyasterone (degree = 16), ecdysone (degree = 15), deoxyandrographiside (degree = 14), aurantiamid (degree = 14), etc. According to the results of PPI network analysis, tumor necrosis factor (TNF), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and interleukin 6 (IL6) may be the key targets of PAD in the treatment of acne. This evidence concerns the gene IL6 and peripheral arterial disease.