In turn, these inflammatory cytokines induce the recruitment of circulating inflammatory cells and EC into tissues, induce the production of angiogenic factors such as fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF), activate EC to acquire the phenotype of Kaposi sarcoma cells, and reactivate HHV-8 (1). This evidence concerns the gene VEGFA and Kaposi's sarcoma.