BRCA1 and ovarian cancer: To identify molecular pathways that are differentially regulated in the context of BRCA1 or BRCA2 mutation in ovarian cancer, we compared the transcriptomic profile of ovarian tumors obtained from patients with HR WT (HRwt; n = 375), BRCA1-mutant (BRCA1mt; n = 16), and BRCA2-mutant (BRCA2mt; n = 15) HGSOC (Table 1).