Because aggressive tumor types such as TNBC or brain metastasis (53–57), are characterized by hyperactivation of cholesterol and lipids biosynthesis and LSS inhibitors were shown to impair metastasis dissemination (58–61), we tested the effects of the LSS inhibitor Ro-48-8071 on cell viability in a TNBC, HCC70 cancer cell line, and observed a dose-dependent reduction up to approximately 30% at 300 nmol/L (Supplementary Fig. S5A). Here, LSS is linked to cancer.